Thank's Simon
since Typo3 Neos 1.1 etc ...
I point virtual host to the Web folder !
<VirtualHost *:80>
DocumentRoot "C:/wamp/www/Neos-2.0/Web/"
# skip the following line for development
SetEnv FLOW_CONTEXT Production
ServerName neos20
</VirtualHost>
I may be other things to do ?